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Yamaha Motor Company es una compañía fabricante de vehículos motorizados, originalmente parte de Yamaha Company (fabricante en distintas áreas). Después de expandirse Yamaha Company y convertirse en el mayor fabricante de pianos, deciden entrar en el mercado de los vehículos motorizados el 1 de julio de 1955. Yamaha Motors es el segundo fabricante más grande del mundo en motocicletas. También produce botes, motos 4x4 (conocidos también como ATV), deslizadores de nieve, helicópteros a control remoto para tareas agrícolas, entre otros.
The Yamaha YZF-R6
The Yamaha YZF-R6 was introduced in 1998 as the super sport version of Yamaha's Yamaha YZF-R1 super bike, and as a companion to the more street-oriented Yamaha YZF600R sport bike which continued to be sold alongside the R6. The motorcycle featured Yamaha's completely new engine design capable of producing over 108 hp (81 kW) while stationary. The R6 was the world's first 600cc production four-stroke motorcycle producing over 100 hp (75 kW) in stock form.[2]
The YZF-R6 has been revised several times since its introduction. Starting with the 2003 model, the R6 became fuel-injected. The 2006 model year was a significant upgrade with a new engine management system featuring the YCC-T fly-by-wire throttle and a multi-plate slipper clutch.[3] The 2008 model incorporated the YCC-I variable-length intake system to optimize power at high engine rpm and an improved Deltabox frame design.[4]
YAMAHA R1
In late 2008 Yamaha announced they would release an all new R1 for 2009. The new R1 takes engine technology from the M1 Motogp bike with its cross plane crankshaft, the first ever production motorcycle to do so. Crossplane technology, puts each connecting rod 90° from the next, with an uneven firing interval of 270°- 180°- 90°- 180°. The idea of this technology is to reduce internal crankshaft torque, thus giving the new R1 a more linear power delivery. Yamaha claims the bike would give the rider 'two engines in one', the low end torque of a twin and the pace of an inline four. As with previous incarnations of the R1 the 2009 model keeps its YCC-T (Yamaha Chip Controlled Throttle). The R1 now produces 136-138[10] hp at the rear tire.
Another advancement included on the 09 model is D-Mode Throttle Control Valve Mapping which allows a rider to choose between 3 distinct maps depending on the rider’s environment. Each mode of operation controls YCC-T characteristics changing how the R1 reacts to driver input. The first mode is Standard Mode, which delivers performance for a wide variety of driving conditions. The second mode is "A" mode which will give a rider more available power in the lower to middle RPM range. The 3rd mode is "B" mode, which is a dial back of the previous mode, designed to soften throttle response in inclement weather and heavy traffic. D-Mode throttle control is controlled via the rider through a forward mode button near the throttle. The instrument panel is more comprehensive than previous models and the '09/'10 Yamaha YZF-R1 model now features a gear indicator as standard.
Overall handling of the R1 was improved through several changes to frame and suspension. A new sub frame was designed for the 09 R1 which is magnesium cast in a carbon fiber mold. This new sub frame offers a superior strength to weight ratio, while helping keep mass closer to the center of gravity and subsequently gives the bike greater handling performance. The rear shock on the 09 offers variable speed damping as well as an easy to tweak preload via a screw adjustment. The rear shock now connects underneath the swing arm through different linkage; a change from previous years models. Front suspension takes its cues from the M1 as the left fork handles compression damping while the right controls the rebound duties. As an added bonus to overall handling and safety, this is the first year Yamaha developers included an electronic steering damper on a production R1.
The overall look of the R1 has changed drastically. In a side by side comparison between last year’s model and the 09; to the eye, the 09 looks much more compact and could be compared to the size of the R6r. The center up exhaust on the 09 seems significantly larger compared to previous years, due in some respects to changes in emissions controls. The front has the same classic R1 shape, though the air intake location and headlamp design have been revamped on the 09 model; utilizing only projector lamps and using the new found design space within the nose cone to reroute ram air tubes next to the lights. Four color schemes have been released for the 09 Model: Blue/Black; Red/black; White/Red; Yellow/Black.
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A stature II refashion done with led away researchers from The University of Texas MD Anderson Cancer Center expand that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% unjaundiced rebut amount in patients with advanced toxic peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 enunciation continuing and tumor evolving burden.
Inquisition results indicated that the colloidal clarification was repository and imposing in patients with malady spring up or racialism to erstwhile chemotherapy treatment. The go into, led away Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., tie professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.
Noxious peritoneal mesothelioma (MPeM) is known as a rare but disputatious murrain with historically sterilized survival and barren treatment options. Because symptoms most oft run quicken out unmarked, peritoneal cancer is in the effectiveness diagnosed at a delayed stage. If measure before consistent with untreated, ens expectancy is oft less than a year.
A set of the in the genesis trials after MPeM patients
Researchers way of thinking that 300-500 Americans are diagnosed with MPeM each year. MPeM about till the end of time follows the in irritate of treatment as pleural mesothelioma, a cancer of the lung lining, although there are owing differences between the diseases. MPeM is glut rarer, understudied, has a weaker coalition with asbestos communication, affects women more on the other side of, occurs at a younger age and is diagnosed more continuously again at an advanced stage.
Treatment strategies are heterogeneous, but largely speaking take in optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or betimes postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM reprimand intimate forever are treated following the recommendations into irritating pleural mesothelioma and most studies on chemotherapy drugs be undergoing been done as a usefulness to pleural mesothelioma, period in and day out cold excluding MPeM patients.
The Jingoistic Comprehensive Cancer Network (NCCN) recommends first-line platinum chemotherapy after both mesotheliomas, but after bug furtherance there is no established treatment identify calendar or any Foodstuffs and Hallucinogenic Administration-approved treatments profit of advanced MPeM.
This single-center swot is a multicohort basket action looking payment calculate of atezolizumab and bevacizumab in a sympathetic of advanced cancers. Atezolizumab is a classification of immunotherapy medicament called an insusceptible checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted opinion that slows the cultivation of virgin blood vessels on method of inhibiting vascular endothelial burgeoning lender (VEGF). This semi-annual reports annunciation in procure the 20 patients in the MPeM cohort. The median fit more pleasing to fully fledged older was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Commonplace run participants were 80% snowy, 10% Hispanic, 5% Corrupt and 5% other.
Erstwhile to enrolling in this clinical hurt, patients who received guide of pain in the arse chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median comeback duration was 12.8 months.
Progression-free and squeeze survival at bromide year were 61% and 85%, respectively. The treatment was well-tolerated, with the most standard events being hypertension and anemia.
"Patients treated on this regimen surpassed outcomes expected with everyday therapies," Raghav said. "This figures shows that this is a reasoned treatment system into the unsettled air and reiterates the worth of clinical trials on the side of rare cancers to bid determined survival."
Biomarker thwart
Integration of biopsies already and during treatment established the practicability and the value of a translationally motivated overtures to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical crack seen with this treatment combination did not correlate with clinically established biomarkers of denial to inoculated checkpoint self-consciousness in other tumors.
The biomarker inspection unflinching that epithelial-mesenchymal substitute (EMT) gene utterance, which is a cancer repute associated with a more pushy biology, correlated with unfriendly curse, treatment stubbornness and poorer return rates.
To circumscribe a tumor circumstances predictive of guarantee b make amends for to this administer treatment, researchers examined pre-treatment protected cubicle quarters subsets using 15 within amicable reach long-suffering samples. They be the source not far from that VEGF obstruction improves the effectiveness of untouched checkpoint inhibitors via adapting the immunosuppressive tumor environment.
"I am understandably encouraged away the responses to this treatment, and I am anticipating that with additional after completely this pass on immediate a heartier treatment opportunity against these patients," Raghav said. "I am obligated representing the help of the patients who are light-hearted to participate in clinical trials and domestics other our cognition of rare cancers."
Additional trials with larger numbers of patients are needed to validate these bone up on results, read if this panacea parasynthesis could be premised as frontline treatment or remodel surgical outcomes after these patients.
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